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Turmeric is one of six supplements causing health issues requiring hospitalization, researchers have found. (Getty Images) Getty Images
STATEN ISLAND, N.Y. — Popular supplements used by more than 15 million Americans may be putting their liver health at risk, according to health researchers.
Research has revealed the extent of the damage being caused by taking popular botanical supplements including turmeric, green tea, the stress-relieving ashwagandha and weight-loss aid Garcinia cambogia.
For this most recent study, University of Michigan health researchers in Ann Arbor looked at data from 2017 to 2021, covering 9,685 people, and found that nearly 4.7% of U.S. adults had used one of the six potentially toxic supplements within the previous 30 days. The resulting paper, “Estimated Exposure to 6 Potentially Hepatoxic Botanicals in U.S. Adults,” appeared in JAMA Network Open this month .
Supplement users were mostly taking these botanicals on their own, not under medical advice, for a range of issues: Turmeric is taken for joint health and arthritis, green tea extract is thought to boost energy levels, G. cambogia is taken for weight loss, black cohosh is taken to manage hot flushes and red yeast rice is taken for heart health.
The study was specifically concerned with green tea extract, not drinking tea, which has no link to liver toxicity – though a limit of eight cups a day is recommended, according to a report in New Atlas, a science and technology publication.
And while news of liver toxicity connected to these supplements is not new, having been reported to be on the rise for some time now, including in this 2022 study , medical researchers are concerned that people are unaware that they come with a serious risk of overdose.
Hospitalizations increased from 7% to 20% over the decade between 2004 and 2014, the new study found.
“Use of herbal and dietary supplements (HDSs) accounts for an increasing proportion of drug hepatotoxicity cases,” researchers, led by Alisa Likhitsup, an assistant professor of gastroenterology, told New Atlas
Drug-induced hepatotoxicity is an acute or chronic liver injury also known as toxic liver disease, with a host of symptoms including yellowing of the skin, fatigue, nausea, rash, itching and upper-right abdominal pain, according to the National Library of Medicine. And, while it can be treated by removing the toxic trigger, it can lead to serious consequences — including the patient needing a liver transplant or even death if it is left untreated.
The researchers are not campaigning for abstinence, but urge users to be vigilant with ingredients and dosages, especially if they’re taking a combination of them or other medications, according to the report.
“In light of the lack of regulatory oversight on the manufacturing and testing of botanical products, it is recommended that clinicians obtain a full medication and HDS use history when evaluating patients with unexplained symptoms or liver test abnormalities,” they wrote in the study. “Considering widespread and growing popularity of botanical products, we urge government authorities to consider increasing the regulatory oversight on how botanicals are produced, marketed, tested, and monitored in the general population.”
Regulatory processes surrounding these supplements are not as stringent as for prescription medicines, and chemical testing of products has revealed inconsistencies between what’s advertised on the bottle and what dose is in a tablet, researchers reported.
“In a previous study, we found that there was a great deal of mislabeling of some of these products,” said Dr. Robert Fontana, a Michigan Medicine a hepatologist, professor of medicine and the study’s senior author.
“We performed analytical chemistry and found about a 50% mismatch between stated ingredients on the label and what they actually contained, which is quite alarming,’' Fontana said. “If you buy a supplement and it says it has a certain ingredient, it’s basically a coin flip if that’s true or not.”
In the studied population, the highest proportion of people consumed turmeric (3.46%), followed by green tea (1.01%), ashwagandha and black cohosh (0.38%), garcinia cambogia (0.27%), and red yeast rice products (0.19%), researchers reported.
And clinical trials into the efficacy of these supplements have not provided robust evidence of their benefits compared to their risks when they’re taken at higher doses, the researchers reported.
Safe amounts of each supplement depends on any prescription medicines an individual may be taking, as well as their baseline liver health and other medical conditions.
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NIH Extramural Nexus
If you are proposing a clinical research study to NIH, you will need to specify whether your research involves an existing dataset or resource as part of the PHS Human Subjects and Clinical Trials Information Form Inclusion Enrollment Report. But what is an existing dataset or resource?
NIH has updated its FAQ and the OER Glossary to clarify that an existing dataset or resource consists entirely of data that has been or is being collected for a different purpose or research question but will now be used to answer a new research question or replicate scientific findings. An existing dataset may be constructed of different types of data including but not limited to survey data, demographic information, test results, health records, genomic information, as well as data to be derived from existing samples of cells, tissues, or other types of materials. It would not be an existing dataset if the new research study will have ongoing or future contact with participants in the original study.
For example, a study examining data from electronic health records (EHRs) may be considered to involve an existing dataset or resource, even if the collection of data in the electronic health records will continue after the study begins. However, if the study team will be contacting the participants, it would not be considered an existing dataset or resource. Check out the FAQs on Working with Existing Datasets or Resources on the Inclusion of Women and Minorities FAQs and the Inclusion Across the Lifespan FAQs webpages for more details on reporting inclusion information for these studies.
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Following a term in which the Supreme Court made consequential rulings on presidential immunity, government regulation of business, abortion and other issues, the court’s public image is little changed from last year.
Pew Research Center conducted this survey to assess the public’s attitudes about the Supreme Court. For this analysis, we surveyed 9,424 adults from July 1 to 7, 2024.
Everyone who took part in this survey is a member of the Center’s American Trends Panel (ATP), a group of people recruited through national, random sampling of residential addresses who have agreed to take surveys regularly. This kind of recruitment gives nearly all U.S. adults a chance of selection. Surveys were conducted either online or by telephone with a live interviewer. The survey is weighted to be representative of the U.S. adult population by gender, race, ethnicity, partisan affiliation, education and other factors. Read more about the ATP’s methodology .
Here are the questions used for this analysis , the topline and the survey methodology .
Fewer than half of Americans (47%) now express a favorable opinion of the court, while about half (51%) have an unfavorable view, according to a Pew Research Center survey conducted July 1-7, 2024.
Opinions of the court have become slightly more positive since last year, when 44% of Americans had a favorable impression. However, favorable views of the Supreme Court remain close to that three-decade low. The court’s favorable rating is 23 percentage points lower than it was in August 2020.
Just 24% of Democrats and Democratic-leaning independents view the Supreme Court favorably. That is unchanged since last year, and ties the court’s lowest favorable rating from either party in more than 30 years.
As recently as 2021 – before the court’s 2022 decision to overturn the federal right to abortion, as well as other controversial rulings – nearly two-thirds of Democrats had a favorable impression of the Supreme Court.
By contrast, Republicans are much more likely to view the court favorably, with 73% holding a positive opinion. Republicans’ opinions of the court have changed much less than Democrats’ views in recent years.
Nearly half of Americans (48%) view the Supreme Court as conservative, while 42% see it as “middle of the road.” Only 7% describe the court as liberal.
Public perceptions of the Supreme Court’s ideology have not changed much in the past year. Since 2020, however, the share of Americans saying the court is conservative has increased 18 points. That year, 56% said the court was middle of the road, while 30% viewed the court as conservative and 12% said it was liberal.
Democrats are much more likely than Republicans to view the Supreme Court as conservative. Seven-in-ten Democrats say the court is conservative, but just three-in-ten Republicans say the same.
By comparison, Republicans are more than twice as likely as Democrats to say the court is middle of the road (59% vs. 25%).
Half of Americans say the Supreme Court has the right amount of power, while 42% say it has too much power. Just 6% say the court has too little power. These opinions have not changed much since 2023, when 51% of Americans said the court had the right amount of power and 40% said it had too much power.
Democrats are nearly three times as likely as Republicans (62% vs. 22%) to say the court has too much power. By contrast, when asked the same question in 2020, similar shares of Democrats (64%) and Republicans (66%) said the court had the right amount of power.
Here’s a closer look at how different groups of Americans see the Supreme Court.
Democrats with lower levels of educational attainment view the Supreme Court more positively than those with higher levels of education. About a third of Democrats with some college or less education (29%) view the court favorably, compared with just 15% of Democrats with at least a bachelor’s degree.
The opposite is true among Republicans. About eight-in-ten Republicans with a postgraduate degree (81%) have a favorable opinion of the court. A smaller share of Republicans with a high school diploma or less education (69%) share this view.
Older Republicans continue to view the court more favorably than younger Republicans do. About eight-in-ten Republicans ages 50 and older (83%) see the court positively, while 63% of GOP adults under 50 say the same.
When it comes to Supreme Court justices keeping their political views out of their decision-making, 18% of Americans say the justices are doing an excellent or good job of this, while 55% say they are doing an only fair or poor job.
Democrats are much more likely than Republicans to say the justices are not doing a good job keeping their personal politics out of their decisions.
About three-quarters of Democrats (73%) say justices are doing an only fair or poor job at keeping their views out of their judgments, while just 6% say they are doing an excellent or good job.
Republicans are more divided in these assessments: 32% say justices are doing an excellent or good job, while 39% say they are doing an only fair or poor job.
Overall, 87% of Americans say the justices should not bring their political views into decision-making; just 11% say they should. Comparable majorities of Democrats and Republicans say the justices should not bring personal politics into decisions.
Note: This is an update of a post originally published July 21, 2023, by Katy Lin and Carroll Doherty. Here are the questions used for this analysis , the topline and the survey methodology .
Joseph Copeland is a research analyst at Pew Research Center .
Most of biden’s appointed judges to date are women, racial or ethnic minorities – a first for any president, most americans favor maximum age limits for federal elected officials, supreme court justices, in divided washington, americans have highly negative views of both parties’ leaders, growing share of americans see the supreme court as ‘friendly’ toward religion, most popular.
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ABOUT PEW RESEARCH CENTER Pew Research Center is a nonpartisan fact tank that informs the public about the issues, attitudes and trends shaping the world. It conducts public opinion polling, demographic research, media content analysis and other empirical social science research. Pew Research Center does not take policy positions. It is a subsidiary of The Pew Charitable Trusts .
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Iran is stepping up its influence campaign aimed at the U.S., researchers at Microsoft said in a new report , adding to the ongoing efforts by Russia and China to sway American public opinion before the presidential election.
Researchers identified websites that they attributed to the Iranian operation, aimed at voters on the political left and right. One website, Nio Thinker, bills itself as “your go-to destination for insightful, progressive news and analysis that challenges the status quo” and hosts articles that bash former President Donald Trump and hail Vice President Kamala Harris as “our unexpected, awkward savior.”
Another site identified by researchers, Savannah Time, poses as a voicey conservative local alt-weekly. “We’re opinionated, we’re noisy, and we’re having a good time,” the about section of the site says. It hosts articles claiming to be written by “the spokeswoman for the International League for Women’s Rights,” arguing for more modest Olympics beach volleyball bathing suits, next to articles lauding Iran’s military might.
The Microsoft Threat Analysis Center noted the sites were likely using artificial intelligence tools to lift content from legitimate U.S. news publications and repackage articles in a way that hides the content’s source.
The group behind the sites, according to Microsoft, is part of a larger Iranian operation, active since 2020, that operates more than a dozen other fake news sites targeting English-, French-, Spanish- and Arabic-speaking audiences. The campaign has not found significant success with a U.S. audience, and the sites’ content has not been shared widely on social media, according to the researchers. But researchers say the sites could be used closer to the election.
Beyond the effort to sow controversy and divide Americans before the vote, researchers said another group linked to the Islamic Revolutionary Guard Corps targeted a “high-ranking official on a presidential campaign” in June with a spear-phishing email from a compromised email account of a former senior adviser and attempted to access an account belonging to “a former presidential candidate.” The report did not name the people who had been targeted.
Iran’s United Nations mission did not immediately respond to a request for comment but denied the reports of meddling in a statement to The Associated Press : “Iran has been the victim of numerous offensive cyber operations targeting its infrastructure, public service centers, and industries. Iran’s cyber capabilities are defensive and proportionate to the threats it faces. Iran has neither the intention nor plans to launch cyber attacks. The U.S. presidential election is an internal matter in which Iran does not interfere.”
Microsoft’s report also noted continued activity by Russia, including an operation by a group researchers call Storm-1516 , which produces propaganda videos in support of Trump and Russian interests and distributes them through a network of fake news websites connected to a former U.S. police officer. China-linked actors, the report said, had also pivoted increasingly to spreading propaganda via video and had leveraged a network of online accounts to stoke outrage around pro-Palestinian university protests.
The researchers reported an expectation that Iran, along with China and Russia, would intensify cyberattacks against candidates and institutions and increase efforts to divide Americans with propaganda and disinformation in the run-up to the election.
Brandy Zadrozny is a senior reporter for NBC News. She covers misinformation, extremism and the internet.
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Researchers found that nearly 4.7% of U.S. adults had used one of the six potentially toxic supplements within the previous 30 days.
It would not be an existing dataset if the new research study will have ongoing or future contact with participants in the original study. For example, a study examining data from electronic health records (EHRs) may be considered to involve an existing dataset or resource, even if the collection of data in the electronic health records will ...
It's almost time to put all of your fantasy football research to good use. The 2024 NFL season is off and running—well, the preseason portion of it at…
Pew Research Center conducted this survey to assess the public's attitudes about the Supreme Court. For this analysis, we surveyed 9,424 adults from July 1 to 7, 2024. Everyone who took part in this survey is a member of the Center's American Trends Panel (ATP), a group of people recruited through national, random sampling of residential ...
Losing the ability to smell may be associated with the risk of heart failure in older adults, even those who say they are in excellent health, according to new research from Honglei Chen, MSU Research Foundation Professor of epidemiology and biostatistics in the Michigan State University College of Human Medicine. "About a quarter of U.S. older adults have poor olfaction, or sense of smell ...
Iran is stepping up its influence campaign aimed at the U.S., researchers at Microsoft said in a new report, adding to the ongoing efforts by Russia and China to sway American public opinion ...